Osteomyelitis pathophysiology
1. Initial response is inflammation, increased vascularity, and edema
2. After 2-3 days, thrombosis of local blood vessels occurs, resulting in ischemia and bone necrosis
3. Infection extends into medullary cavity and under periosteum, may spread to adjacent soft tissues and joints
4. Bone abscess forms, containing dead bone tissue (sequestrum)
5. New bone growth (involucrum) forms around sequestrum
6. Chronic infected sequestrum remains, producing recurring abscesses