Metabolism

• Metabolism (Biotransformation)


  The aim of drug metabolism is to change lipid soluble drugs to water soluble metabolites to be easily excreted.
• Site metabolism

  1. Liver (Hepatic) is the main site for biotransformation
  2. Lung : Nicotine, Prostaglandins & Angiotensin (ACE).
  3. Kidney: Vitamin D
  4. G.I.T. & Gut flora : Tyramine & Histamine
  5. Skin : Vitamin D
  6. Plasma (Cholinesterase) → Succinylcholine