Recombinant cytokines

• Which 2 recombinant cytokines can be used to treat renal cell carcinoma?

  Aldesleukin (recombinant IL-2) and interferon-α
• Which 2 recombinant cytokines may be useful in treating autoimmune thrombocytopenia by acting as platelet stimulators?

  Romiplostim (thrombopoietin analog) and eltrombopag (thrombopoietin receptor agonist)
• Which recombinant cytokine may be used to treat multiple sclerosis?

  Interferon-β (IFN-β)
• What are 3 clinical indications for treatment with interferon-α (IFN-α)?

  Chronic hepatitis B, chronic hepatitis C, renal cell carcinoma
• Which 2 recombinant cytokines could be used to treat leukopenia?

  Filgrastim (G-CSF) and sargramostim (GM-CSF), which aid in the recovery of granulocyte and monocyte counts
• Which recombinant cytokine can be used to treat chronic granulomatous disease?

  Interferon-γ
• Which bone marrow–stimulating agent can be used to treat renal failure–associated anemias?

  Epoetin alfa (an erythropoietin analog)
• Which cytokine is aldesleukin a recombinant form of?

  Interleukin-2
• Which 2 types of cancer can recombinant interleukin-2 (IL-2) be used to treat?

  Metastatic melanoma and renal cell carcinoma