Therapeutic Antibodies

Created by

Sam Kaz

Cards (28)

What is the target of Adalimumab and Infliximab?
Soluble TNF-α
What are the indications for Adalimumab and Infliximab?
IBD, rheumatoid arthritis, ankylosing spondylitis, psoriasis
What is important to screen for when using Adalimumab and Infliximab?
Screen patients for TB due to risk of reactivation.
How does Etanercept differ from Adalimumab and Infliximab?
Etanercept is a decoy TNF-α receptor and not a monoclonal antibody
What protein does Eculizumab target?
Complement protein C5
What is Eculizumab used to treat?
Paroxysmal nocturnal hemoglobinuria
What cytokine does Guselkumab target?
IL-23
What condition is Guselkumab indicated for?
Psoriasis
What cytokine do Ixekizumab and Secukinumab target?
IL-17A
What are the indications for Ixekizumab and Secukinumab?
Psoriasis, psoriatic arthritis
What does Natalizumab target?
α4-integrin
What are the indications for Natalizumab?
Multiple sclerosis, Crohn disease
What is the risk associated with Natalizumab?
Risk of PML in patients with JC virus
What cytokines does Ustekinumab target?
IL-12/IL-23
What conditions is Ustekinumab used to treat?
Psoriasis, psoriatic arthritis
What integrin does Vedolizumab target?
α4-integrin
What is the indication for Vedolizumab?
IBD
What is the mechanism of action of Vedolizumab?
Gut-specific anti-integrin, preventing migration of leukocytes to the gastrointestinal tract
What does Denosumab target?
RANKL
What is Denosumab used for?
Osteoporosis; inhibits osteoclast maturation
How does Denosumab affect bone density?
It helps make dense bones.
What factors does Emicizumab mimic?
Factor IXa and X
What is Emicizumab used to treat?
Hemophilia A
How is Emicizumab classified in terms of its specificity?
Bispecific; mimics factor VIII.
What does Omalizumab target?
IgE
What is Omalizumab used for?
Refractory allergic asthma; prevents IgE binding to FcεRI
What protein does Palivizumab target?
RSV F protein
What is the indication for Palivizumab?
RSV prophylaxis for high-risk infants