Immunodeficiency

• what is primary immunodeficiency

  genetically acquired
• secondary immunodeficiency

  acquired from the environment
• what are the components of the innate immune system

  eosinophil

  epithelial barrier

  mast cell

  basophil

  natural killer

  neutrophil

  dendritic cell

  complement

  macrophage
• what happens during adaptive immunity

  impaired B and T cell function
• what is an example of primary immunodeficiency

  SCID and DiGeorge
• what is an example of secondary immunodeficiency

  B cell malignancy

  AIDS
• what happens in CGD

  genetic defect in NAPH oxidase
• what happens during LAD

  affected leukocyte adhesion
• what happens during SCID

  impaired B and T cell function
• how can you treat SCID

  stem cell transplant

  gene therapy
• how can you treat DiGeorge syndrome

  individualised by symptoms
• what happens during DiGeorge syndrome

  22q11.2 gene microdeletion

  impaired T cell function
• what happens during B cell malignancy

  decreased antibody production

  develop cancer
• how to treat B cell malignancy

  chemotherapy

  radiotherapy
• what happens during AIDS/HIV

  T cell destruction
• how to treat HIV/AIDS

  antiretroviral therapy