Pharmacology: Antipsychotic & Antianxiety Drugs

• What drugs are used to suppress the symptoms of schizophrenia and other psychotic conditions?

  Antipsychotics
• The basic chemical structure of a large number of antipsychotics that are similar in structure and pharmacological action is called?

  phenothiazine
• How long does it typically take for antipsychotic drugs to take effect or fully develop?

  Several weeks
• Which of the following are common adverse effects of antipsychotic drugs?


  • Visual disturbances
  • Constipation
  • Dry mouth
• Butyrophenones are more potent than the ______.

  phenothiazines
• Antipsychotics work on the limbic system and the _____.

  cerebral cortex
• In addition to a higher incidence of EPS, butyrophenones can cause the potential development of which of the following?

  • Neuroleptic syndrome
  • Tardive dyskinesia
• Phenothiazine drugs are similar in which of the following ways?

  • Pharmacologic action
  • Structure
• The trade name for thiothixene is ______.

  Navane®
• The main effects of antipsychotic drugs are to reduce which of the following in patients with mental illness?

  • Bizarre behavior
  • Hallucinations
  • Irrational thought disorder
• What is thiothixene associated with?

  Higher incidence of EPS
• What is a more serious adverse effect of antipsychotic drugs involving involuntary movements?

  Tardive dyskinesia
• Which of the following are among the most frequent adverse effects of thioxanthenes?

  • Postural hypotension
  • Drowsiness
• Butyrophenones produce a lower incidence of peripheral effects including which of the following when compared to phenothiazines?

  • Antihistaminic
  • Anticholinergic
  • Alpha blockade
• Atypical antipsychotics are associated with a lower incidence of EPS because they have less effect on ____ receptors.

  dopamine
• There is an increased incidence of ____ symptoms with the butyrophenones.

  EPS
• Common side effects of aripiprazole include which of the following?

  • Constipation
  • Dizziness
  • Anxiety
  • Sleep disturbances
• Thioxanthenes exert antipsychotic effects by blocking ______.

  dopamine
• Clozapine can cause sedation, seizures, weight gain, and ____.

  agranulocytosis
• Which of the following are true of the effects of thiothixene compared to those of chlorpromazine?

  • Less sedation
  • Fewer anticholinergic effects
• Patients who become allergic to thioxanthene drugs may develop which of the following?

  • Dermatitis
  • Blood disorders
  • Obstructive jaundice
• With the use of risperidone, there is the risk of weight gain and ____ hypotension.

  postural
• Atypical antipsychotics are associated with which of the following adverse effects?

  • Weight gain
  • Diabetes mellitus
  • Hyperlipidemia
• During physical exertion, aripiprazole can cause ______.

  fever
• Which of the following are prominent adverse effects of clozapine?

  • Sedation
  • Hypotension
• Which of the following are the adverse effects of olanzapine?

  • Postural hypotension
  • Weight gain
  • Dizziness
• What is thiothixene associated with?

  Higher incidence of EPS
• Antipsychotics should be used in pregnancy only when ______.

  the benefits outweigh the risks
• When does the incidence of sedation and EPS increase when using risperidone?

  At higher doses
• Antipsychotic drugs produce anticholinergic, alpha-blocking, antihistamine, and ______ effects.

  CNS depressing
• The preferred therapy for schizophrenia and psychosis are ____ antipsychotic drugs.

  atypical
• A condition that causes rapid heartbeat, sweating, nausea, loss of appetite, trembling, and emotionalism is known as ____.

  anxiety
• A condition that causes rapid heartbeat, sweating, nausea, loss of appetite, trembling, and emotionalism is known as ____.

  anxiety
• Olanzapine has shown effectiveness in the treatment of which of the following?

  • Acute mania
  • Bipolar disorder
• Which of the following were the first benzodiazepine drugs introduced and have been available for over 50 years?

  • Chlordiazepoxide (Librium)
  • Diazepam (Valium)
• Use of antipsychotic drugs during ____ should be avoided if possible.

  pregnancy
• Which of the following are short-acting benzodiazepines that are used as hypnotics?

  • Triazolam (Halcion)
  • Temazepam (Restoril)
• Antipsychotic drugs produce anticholinergic, alpha-blocking, antisistaminic, and CNS depressing effects so they will ____ other drugs that produce the same pharmacologic effects.

  interact with
• Benzodiazepines produce sedation and hypnosis by which of the following actions?

  Increasing the action of GABA
• Which of the following are advantages of using atypical antipsychotic drugs for the treatment of schizophrenia and psychosis?

  • Lower incidence of sedation
  • Lower incidence of EPS
  • Lower incidence of neurological disturbances