HEMA-HEMA-HEMA

• OXYGEN DISSOCIATION CURVE

  ♥ The curve produced when the two variables are plotted on a graph

  ♥ Sigmoid in shape

  
  

  SHIFT TO THE LEFT

  Ph and Hb affinity for O2: Increase

  PCO2, TEMPERATURE, 2-3 DPG: DECREASE

  
  

  
  

  SHIFT TO THE RIGHT

  
  

  Ph and Hb affinity for O2: DECREASE

  PCO2, TEMPERATURE, 2-3 DPG: INCREASE
• Bohr effect


  Demonstration the relationship between blood pH and oxygen affinity of Hb
• Erythrocyte Destruction


  ❖ EXTRAVASCULAR HEMOLYSIS

  Also known as the Macrophage mediated hemolysis

  90% : aged red cell destruction

  occurs within the RES

  ❖ Intravascular/Fragmentation Hemolysis

  Responsible for ≤10% of RBC destruction

  Occurs within blood vessel
• Laboratory Assessment

  ◻ Serum iron (SI)

  ◻ Total iron-binding capacity (TIBC)

  ◻ Percent transferrin saturation

  ◻ Zinc protoporphyrin
• Hemoglobin Derivatives


  CARBOXYHEMOGLOBIN (HbCO)

  ❖ CHERRY RED COLOR OF SKIN

  ❖ Reversible

  METHEMOGLOBIN /HEMIGLOBIN (Hi)

  ❖ Causes CHOCOLATE BROWN discoloration of blood

  ❖ Reversible

  SULFHEMOGLOBIN

  ❖ Blood is MAUVE-LAVENDER

  ❖ IRREVERSIBLE