RENAL CORPUSCLE

• RENAL CORPUSCLE

  ● filtration apparatus of the nephron

  ● each corpuscle consists of two main elements
• Two Main Elements

  = Glomerulus

  • cluster of blood vessels
  • fenestrated capillaries
  • connective tissue ~ Mesangial cells
  • extraglomerular
  • intraglomerular
• Two Main Elements

  = Glomerular / Bowman's Capsule

  • Double-walled envelope
  • comprise of the inner visceral and outer parietal layer
• Renal Corpuscle

  ● produces glomerular ultrafiltrate

  ● spherical structure

  ● an initial dilated part enclosing a tuft of capillary loops and the site of blood filtration
• MEDICAL APPLICATION

  = Polycystic kidney disease


  = an inherited disorder in which normal cortical organization of both kidneys is lost due to the formation of multiple, large, fluid-filled cysts. The cysts may arise from any epithelial cells of the nephron and can lead to gross kidney enlargement and loss of renal function.
• = EFERENT ARTERIOLES enter while the AFFERENT ARTERIOLES leave the glomerulus at vascular pole while ultrafiltrate leave corpuscle at renal pole
• = Capillaries forming glomerulus are fenestrated and their endothelium rests on a thick basal lamina
• = Parietal layer

  • formed by simple squamous cells
• = Visceral layer

  • formed by podocytes
• = Connective tissue stroma of the glomerulus is constituted by mesangial cells, which support the glomerular capillaries
• Function of Mesangial cell

  • phagocytic
  • contractile
  • support