antibacterials (finals)
Cards (147)
- cancer chemotherapy
- name all the anticancer drugs
- drugs under this alkylating agent _
- antimetabolites drugs under these are:
- what are the drugs under these natural products
- antitumor antibiotics drugs _
- miscellaneous drugs _?
- what are the hormonal drugs_
- MOA of resistance to anticancer drugs
- exert their actions selectively on cycling cells _
- cell cycle-nonspecific (CCNS) drugs
- log-kill hypothesis
- cancer treatment modalities
- it is a form of tetrahydrofolate that is accumulated more readily by normal than by neoplastic cells, bypasses the dihydrofolate reductase step in folic acid synthesis, administered for the toxicity with high doses of methotrexate.
- it traps acrolein released from cyclophosphamide, reduces the incidence of hemorrhagic cystitis.
- it inhibits free radical formation, affords protection against the cardiac toxicity of anthracyclines.
- what drugs are under alkylating agents
- give examples of nitrogen mustards drugs
- give examples of nitrosoureas
- give example of alkyl sulfonates drug
- other drugs under alkylating agents are_
- form reactive molecular species that alkylate nucleophilic groups on DNA bases, particularly the N-7 position of guanine, leading to crosslinking of bases, abnormal base-pairing, and DNA strand breakage.
- what does the tumor cell resistance do to alkylating agents
- suppress the immune system. to treat cancer of the ovaries, breast, blood and lymph system and nerves (mainly in children)
- one of the breakdown products_
- uses of cyclophosphamide
- give adverse effects of cyclophosphamide:
- this is spontaneously converts in the body to a reactive cytotoxic product
- give some uses of mechlorethamine
- give toxicity of mechlorethamine
- it less nephrotoxic than cisplatin, less likely to cause tinnitus and hearing loss, has greater myelosuppressant actions.
- what drug is less nephrotoxic than cisplatin?
- dose-limiting neurotoxicity
- forms hydrogen peroxide, generates free radicals that cause DNA strand scission, orally active, penetrates into most tissues including the cerebrospinal fluid, hepatic elimination.
- give one use of procarbazine
- toxicity of procarbazine
- toxicity of BCNU (carmustine) and CCNU(lomustine)
- it is used in chronic myelogenous leukemia, causes adrenal insufficiency, pulmonary fibrosis, skin pigmentation
- it is the adjuncts in the management of brain tumors
- it is used in regimens for Hodgkin's lymphoma