Form of nutrition used by most animals where they ingest and then digest food, absorbing nutrients
They possess a specialised digestive system
Examples include herbivores (plant material), carnivores (animal material), omnivores (plant and animal material) and detritivores (dead or decaying material)
Protoctista such as amoeba are holozoic heterotrophs. They absorb nutrients directly through their cell membrane by diffusion, ingesting larger molecules by endocytosis and fluids by pinocytosis into food vacuoles. Lysosomes fuse with the vacuoles and release digestive enzymes. Nutrients are absorbed through the membrane of the food vacuole and waste is egested by exocytosis.
Some larger organisms have a single body opening; e.g. Hydra, which ingests prey through the mouth and the digested products move into the body cavity. More developed organisms possess a tube gut, ingesting at one end and egesting at the other.