Pk materi

• Acetazolamide


  • Indication: Glaucoma
  • MOA: Inhibits carbonic anhydrase enzyme, increases bicarbonate excretion
  • Side effects: Dizziness, blurred vision
• Mannitol


  • Indication: Acute renal failure
  • MOA: Osmosis, causes water loss
  • Side effects: Angina, hypotension
• Furosemide


  • Indication: Edema associated with heart failure, hypertension
  • MOA: Inhibits Na-K-Cl cotransporter, prevents reabsorption
  • Side effects: Thirst, dry throat
• Hydrochlorothiazide


  • Indication: Hypertension, edema, heart failure
  • MOA: Inhibits Na-Cl symporter, increases Na and water excretion
  • Side effects: Hypotension, glaucoma, electrolyte changes
• Spironolactone


  • Indication: Hypokalemia, hypertension
  • MOA: Antagonizes aldosterone, increases K excretion
  • Side effects: Hypokalemia, risk factors