SEM2 - ANTIHELMETHICS

• Inhibits microtubule synthesis


  Albendazole
• Mebendazole (___ ®)


  Antiox
• Inhibits microtubule synthesis Depletes glucose


  Mebendazole /Antiox
• Ascaris, enterobius, and trichuris infections


  Mebendazole
• Depolarizing neuromuscul ar agent (nicotinic receptors)


  Pyrantel Pamoate
• Ascaris, hookworm and enterobius infestations


  Pyrantel Pamoate
• Flaccid paralysis of helminth (Blocks response of helminth muscle to Ach)


  Piperazine
• Ascaris and pinworm


  Piperazine
• Targets GABA


  Ivermectin
• ____Onchocercavolv ulus (____)


  IVERMECTIN- river blindness
• Also affects microtubular aggregation


  Thiabendazole
• ___Strongyloidiasis (___)


  Thiabendazole-threadworm
• Diethylcarbamazine


  Filariasis
• Filariasis


  Diethylcarbamazine
• Increases membrane permeability to calcium contraction ---vacuolization → parasite death


  Praziquantel
• For intestinal cestodes only: T. saginata, D latum, H. nana


  Niclosamide
• Inhibits oxidative phosphorylati on in mitochondria of cestodes


  Niclosamide