Binds to 30s Ribosomes

• (Streptomycin, Amikacin, Gentamicin, Netilmicin, Neomycin, Tobramycin


  AMINOGLYCOSIDES
• derived from Streptomyces


  mycin
• derived from Microspora


  micin
• AE: Ototoxicity, Nephrotoxicity, Neuromuscular blockade


  AMINOGLYCOSIDES
• Doxycycline, Minocycline, Tetracycline, Demeclocycline


  TETRACYCLINES
• Broadest spectrum antibiotic (gram (+), gram (-), spirochetes, mycoplasma, rickettsia, chlamydia)


  Tetracycline
• Contain four fused rings with a system of conjugated double bonds


  Tetracycline
• AE: Gastric discomfort, deposition in the bones and primary dentition causing discoloration and hypoplasia of the teeth and a temporary stunting of growth, hepatotoxicity, phototoxicity (demeclocycline), vestibular problems (minocycline


  TETRACYCLINES
• ingestion of expired tetracycline


  Fanconi-like syndrome
• AE: epigastric distress, cholestatic jaundice (estolate form of )


  erythromycin
• (Ilotycin)


  Erythromycin
• Preferred drug for Legionnaire's disease, Mycoplasma pneumoniae and Campylobacter, Chlamydial infections, Diphtheria, Pertussis • DOC ?


  Pen G allergy
• Used with Omeprazole or Lansoprazole (H.pylori eradication)


  Clarithromycin
• , OD - For nongonococcal urethritis (Chlamydia, LRTI, PID, pharyngitis, Legionnaire's)


  Azithromycin
• For abdominal and female genitourinary tract infections caused by B. fragilis (DOC: )


  Vancomycin
• (S. venezuelae)


  CHLORAMPHENICOL
• • For typhoid fever ( -new DOC), meningococcal infections and H.influenza infections in cephalosporin-allergic patients, anaerobic infections


  Ceftriaxone
• • Precautions and monitoring: i. Bone marrow suppression (dose-related) ii. Aplastic anemia (non-dose related) iii. Gray Baby Syndrome (neonates)


  CHLORAMPHENICOL