Insulinomas

• Epidemiology:

  • Most common type of PanNETs

  • Less than 10% = Malignant potential
• Macroscopic Features:

  • Small, <2cm

  • Most common, solitary lesions

  • Localised to the pancreas
• Microscopic Findings:

  • Regular cords of monotonous cells

  • Orientation to the vasculature

  • Amyloid deposits in the extracellular tissue
• Clinical Features:

  • Attacks of Hypoglycaemia

  • CNS manifestations

  • ➢ Confusion
  • ➢ Stupor
  • ➢ Loss of consciousness