C. sinensis & O. felineus

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Created by
yami

Cards (16)

  • C. sinensis is prevalent in countries like China, Taiwan, Japan, Korea, and Vietnam that's why it's called Chinese Liver fluke
  • Both C. sinensis and O. felineus' means of infection is via ingestion of freshwater with metacercaria
  • Both C. sinensis and O. felineus infective stage is Metacercaria
  • C. sinensis & O. felineus intermediate Hosts:
    • 1st IH: Snail
    • 2nd IH: Cyprinoid freshwater fish
  • C. sinensis reservoir hosts are Dogs and Cats
    • C. sinensis final host is Man
    • O. felineus final host is Cats
  • Both C. sinensis and O. felineus' habitat is Bile duct, Gallbladder
  • Parasites of cats and dogs with few reported cases of human infections particularly in Poland and Serbia
    Opisthorchis felineus
  • Opisthorchis felineus is also called Cat Liver Fluke or Serbian Liver Fluke
  • Similar to the adult worm of C. sinensis but the Testes is lobed and is arranged obliquely
    O. felineus
    • Leaflike, flat, spatulated shape
    • Two large, highly branched testes located in the posterior third
    • Has a larger oral sucker than its ventral sucker
    C. sinensis
    • Has a small comma-shaped process at the abopercular end
    • Old-fashioned light bulb appearance
    C. sinensis
  • PATHOGENESIS AND CLINICAL FEATURES of C. sinensis
    • local trauma and irritation
    • fibrosis of biliary duct
    • Increased risk for Hepatocellular carcinoma and cholangiocarcinoma
    • Light infections (<100 flukes) - asymptomatic or have non-specific symptoms
    • Moderate infection (101-1,000) - Fever, diarrhea, edema, hepatomegaly
    • Heavy infection (up to 25, 000) - Acute symptoms of fever, abdominal pain then followed by chronic complications (Hepatitis, cholangitis, cholecystitis)
  • Diagnosis for O. felineus and C. sinensis are:
    • Direct Fecal Smear
    • ELISA - Has a high sensitivity and moderate degree of specificity
    • Polymerase Chain Reaction - 100% specificity; no cross reaction with Opisthorchis spp.
    • Cholangiography - Radiographic features of biliary clonorchiasis
  • Praziquantel: drug of choice for both C. sinensis and O. felineus