Bone

• Bone Cells – maintaining the skeletal integrity
• Osteoblasts - Cells responsible for bone formation. They secrete osteoid, a collagen framework that mineralizes to form bone tissue.

  
• Osteoclasts - Cells responsible for bone resorption, breaking down bone tissue by secreting enzymes that dissolve the mineralized matrix and release minerals like calcium into the bloodstream.

  
• Osteogenic cells - Stem cells found in bone marrow and periosteum that differentiate into osteoblasts, contributing to bone formation and repair.

  
• Osteocytes - Mature bone cells embedded within mineralized bone matrix. They maintain bone tissue integrity, regulate mineral metabolism, and participate in bone remodeling.

  
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  Bone Lining Cells - Specialized cells found on the surface of bone tissue that regulate bone remodeling, mineral metabolism, and may contribute to bone repair and regeneration.
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  Bone Remodeling - The continuous process in which bone tissue is broken down (resorption) and rebuilt (formation). This process is crucial for maintaining the strength and integrity of the skeleton, as well as regulating mineral balance in the body.
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  Disorders Affecting Bone Cells: Various disorders include:

  • Osteoporosis - Bones become weak and brittle due to loss of bone density.
  • Paget's Disease - Bone tissue becomes thickened and deformed.
  • Bone Cancer - Examples include osteosarcoma, a type of bone cancer affecting bone cells.