Some bacteria develop resistance to antibiotics
Some microbes such as influenza have so many different strains that a single vaccine cannot protect against all of them
Most viruses resist antiviral drugs
New infectious agents occasionally arise such as HIV and Corona virus
Some microbes localize in the areas of the body that make treatment difficult
Opportunistic organisms can cause infection in immunocompromised patients
Most people have not received immunization
Increased air travel can cause the spread of the virulent organism to a heavily populated area in hours
Use of biological warfare and bioterrorism with organism such as anthrax and plague is an increasing threat to public health and safety throughout the world
The expanded use of immunosuppressive drugs and invasive procedures increases the risk of infection