CF

• Treatment for Cystic fibrosis: lumacaftor (helps with gene folding, move channel to cell surface) + ivacaftor (stabilises CFTR protein, binds to non-functional channel and allows Cl to move through)
• pancreatitis causes; GET SMASHHED (gallstones, ethanol, trauma, steroids, mumps, autoimmune disease, scorpion sting, hypercalcaemia, hypertriglyceridemia, ERCP, drugs)
• trypsinogen activation influenced by: SPINK 1 (reduces inactivation). CASR (degradation). PRSS1 (activation). CTRC.
• zymogen granule forms a phagopore --> forms a phagosome --> forms an autophagosome that fuses with a lysosome to become an autolysosome --> finally autodigestion