16. Renal Pathology H - Cox

• Acute Interstitial Nephritis (AIN) - characterized by inflammatory infiltrate and edema within interstitium
• AIN - common cause of acute kidney injury - due to drug
• DI-AIN or allergic interstitial nephritis - arise from

  • interstitial antigen trapping --> inflammation
  • tubular cell drug metabolism --> BM or matrix deposition
• Analgesic nephropathy - due to chronic excessive intake of analgesics
• Analgesic nephropathy - sequence of injury

  1. ** papillary necrosis
  2. chronic tubulointerstitial nephritis - fibrosis + thick BM
• Viral Nephropathy - BK polyomavirus

  • necrosis & desquamation
  • Sloughed infected tubular epithelial cells - homogenous ground glass inclusions