Rbc maturation

• Order of blood cell development

  • Pronormoblast
  • Basophilic normoblast
  • Polychromatophilic normoblast
  • Orthochromatophilic normoblast
  • Reticulocyte
  • Mature RBC
• Muoloblast


  The earliest recognizable precursor stage in BM
• Most of the iron destined for hemoglobin synthesis is taken into the cell at this stage
• Detectable hemoglobin synthesis occurs at this stage
• This is the last stage with nucleoli
• This is the first stage capable of hemoglobin synthesis
• This is the last stage capable of mitosis
• Hemoglobin appears for the first time at this stage
• This is the last nucleated stage
• This is the first stage incapable of mitosis
• This is the last stage of hemoglobin synthesis
• This is the first/earliest stage normally found in the circulation
• This is the last immature red blood cell stage
• This stage is used to assess the bone marrow function
• Mature stage
• The primary function of mature RBC is to transport oxygen and carbon dioxide
• Mature RBC has an absence of nucleus, mitochondria, and ribosomes
• First recognizable stage in the BM

  Muoloblast
• RBC maturation is observed from Muoloblast in light microscopy