An action potential reaches the presynaptic terminal, it causes neurotransmitter to be released from the neuron into the synaptic cleft, (a gap between the presynaptic axon terminal and the postsynaptic dendrite). After travelling across the synaptic cleft, the transmitter will attach to neurotransmitter receptors on the postsynaptic side and positive ions (Na, Ca, + K) will travel through channels that span the membrane.