This is a result of a deletion mutation, it changes how every triplet is grouped after point of mutation.
What is a substitution mutation?
This is when one base is replaced by another
What are the three possible outcomes of a substitution mutation?
Silent mutation-no effect on protein sequence because triplet codes for the same amino acid.
Missense mutation-A different amino acid is coded for by the triplet.
Nonsense mutation-the substitution triplet codes for a stop codon.
What can cause mutation?
Mutations occur spontaneously, but mutagenic agents increase the probability of a mutation occurring.
e.g.-UV, radiation, chemicals
How does a mutation lead to the production of a non-functional enzyme?
This causes a change in the base sequence, which causes a change in the order of amino acids(primary sequence of protein). This means a change in the hydrogen, Iodine and disulphide bonds, resulting in a different tertiary structure. As a result there is a different active site, which is not complementary to the substrate, so an enzyme-substrate complex cannot form.
Why don't all mutations cause a change in the structure of a polypeptide?
The triplet codes for the same amino acids, so the protein has the same primary structure
Mutation occurs in introns, which are non-coding for polypeptides.
