Multiple Sclerosis

• Multiple Sclerosis (MS)


  Is an autoimmune disorder that causes destruction of myelin sheath of nerve fibers in the brain and spinal cord (CNS). It is characterized by remissions and exacerbations.
• MS: Manifestations

  • Brain - paralysis
  • Eyes - optic neuritis (blindness; diplopia)
  • Spinal Cord - paresthesia
  • Charcot's Triad: Intention tremors, aphasia, nystagmus
• MS: Manifestations

  Uhthoff's Sign - It is characterized by a temporary worsening of MS symptoms when your body's temperature is raised by fever, exercise, or using a hot tub or sauna.
• MS: Manifestations

  Lhermitte's sign is fast but painful electrical sensation that travels from your neck down your spine.
• MS: Pharmacotherapy

  • Muscle Relaxants. To relieve muscle spasm. Ex - Baclofen
  • Immunosuppressants. To reduce relapse of MS. Ex - Azathioprine; Cyclophosphamide
• MS confirmatory test: MRI to reveal plaques