Importance of 1st structure for 3rd?

• Why is primary structure important for tertiary structure:

  • The order of amino acids in the primary sequence of the polypeptide
  • Determines the final 3D structure of the protein and so its function
  • A change in the sequence of amino acids
  • Changes the interactions between R-groups of amino acids
  • So hydrogen, ionic, disulfide bridges will form in different places
  • So its final 3D structure will be different
  • And so the protein's function will change