Immune thrombocytopenia

• What is immune thrombocytopenia?


  Immune mediated reduction in the platelet count - antibodies are against the glycoprotein IIb/IIIa or ib-V-IX complex
• What type of hypersensitivity reaction in ITP?


  Type 2
• What are some features of ITP?


  Bruising

  Petechial or purpuric rash
• What are some investigations done for ITP?


  FBC

  Blood film

  Bone marrow examinations - only done if there are atypical features
• What features would require a bone marrow examination in ITP?


  Lymph node enlargement

  Splenomegaly

  Hihg/low white cells

  Failure to respond to treatment
• What is the management for ITP?


  Normally no treatment is needed
• What are some mangement options if platelet count is very low?

  Oral/IV corticosteroids

  IV immunoglobulins

  Platelet transfusion (emergency)
• What infection preceded ITP?


  Self-limiting viral infection