Ketone bodies

• What are the three compounds known as ketone bodies?

  Acetone, acetoacetate, and β-hydroxybutyrate
• Which of the ketone bodies is not a true ketone?

  β-hydroxybutyrate
• Where does ketogenesis primarily occur in the body?

  In the liver
• What is the intracellular location of ketogenesis?

  In the mitochondria
• What is the precursor for ketogenesis?

  Acetyl CoA
• From where is Acetyl CoA derived?

  From fatty acid oxidation and ketogenic amino acids
• What is the first ketone body produced during ketogenesis?

  Acetoacetate
• How are β-hydroxybutyrate and acetone derived from acetoacetate?


  β-hydroxybutyrate is reduced, and acetone is spontaneously decarboxylated
• How is acetoacetyl CoA formed?

  By the condensation of two acetyl CoA molecules