DISORDERS AND DISEASES

• Single-gene Disorders - is a mutation that affects only one gene. It is also known as Mendelian / Monogenetic Inheritance. SGD has several patterns of genetic inheritance

  SGD has several patterns of genetic inheritance
• Single-gene Disorders

  Genetic Disorder:

  • Cystic Fibrosis
  • Genotype:
  • Autosomal recessive

  Phenotypic Effects:

  • life-threatening respiratory illness and blockage; digestive problems; salty sweat

  A) MUCUS

  
• Single-gene Disorders

  Genetic Disorder:

  • Sickle Cell Anemia

  Genotype:

  • Autosomal recessive

  Phenotypic Effects:

  • sickle-shaped red blood cells; reduced oxygen- carrying capacity

  A) blocking blood flow

  
• Single-gene Disorders

  Genetic Disorder:

  • Huntington's Disease

  Genotype:

  • Autosomal Dominant

  Phenotypic Effects:

  • neurological disease fatal in middle-aged; uncontrollable twitching
• Single-gene Disorders

  Genetic Disorder:

  • Red-Green Colorblindness

  Genotype:

  • X-linked recessive

  Phenotypic Effects:

  • inability to distinguished color red and green; reduced night vision
• Single-gene Disorders

  Genetic Disorder:

  • Hemophilia A

  Genotype:

  • X-linked recessive

  Phenotypic Effects:

  • lack of blood-clotting; can result in fatal hemorrhage
• Single-gene Disorders

  • Cystic Fibrosis
  • Sickle Cell Anemia
  • Huntington's Disease
  • Red-Green Colorblindness
  • Hemophilia A