natural anticoagulants

• Which three natural anticoagulants are considered important?

  Protein C, Protein S, and Antithrombin.
• How does Protein C regulate coagulation?

  By inactivating Factors V and VIII in conjunction with Protein S.
• What causes activated protein C resistance?

  An inherited risk factor for thrombosis caused by the Factor V Leiden mutation.
• How is activated protein C resistance detected?

  By a PCR-based test.
• What is the role of Antithrombin in coagulation?


  It inhibits thrombin along with several other coagulation factors.
• What are the key features of Protein C, Protein S, and Antithrombin deficiencies?

  • Increased risk of venous thrombosis
  • Can be categorized into Type I (low expression and low activity) and Type II (normal expression and low activity)
• What is the primary function of Protein C?

  To regulate the activity of coagulation Factors Va and VIIIa.
• How is Protein C activated?

  By partial proteolytic cleavage through the Thrombin/Thrombomodulin complex.
• What is the role of Thrombomodulin in coagulation?

  It converts thrombin from a procoagulant to an anticoagulant enzyme.
• What is the function of the endothelial Protein C receptor (EPCR)?

  To bind Protein C and enhance its activation by the Thrombin-Thrombomodulin complex.