Genetically modified foods may have potentially adverse effects on human health
The 'new' genes may have an effect on organisms in the environment of GM crops. (if a gene makes a plant resistant to herbicides is transferred into the gene pool of weeds, the weeds may become resistant)
The high cost of GM seed and the fact that farmers are dependent on seed companies to purchase new seeds every year, increases the cost of food production.
Many people are opposed to the concept of mixing genes from different organisms as they view this as tampering with nature
People of different faiths or cultures, even vegetarians, are against genetic engineering, because GM food may contain the genes of prohibited of avoided foods