AP reaches end of presyn
Ca2+PC open
Ca2+ enters synaptic knob by facilitated diffusion
Influx of Ca2+ = synaptic vesicles fuse with presyn membrane
Release ACh into synaptic cleft
ACh molecules diffuse across cleft
Bind to receptor sites of Na+PC
Na+PC open
Na+ diffuse in rapidly along concentration gradient
Influx of Na+ causes new AP in postsyn
AChE hydrolyses ACh into choline and ethanoic acid
Diffuse back across cleft into presyn for recycling
ATP release by mitochondria used to recombine choline and ethanoic acid into ACh
Na+PC close (no ACh)
