SYNAPTIC TRANSMISSION

    Cards (4)

    • SYNAPTIC TRANSMISSION (CHOLINERGIC SYNAPSE)?
      1. AP reaches end of presyn
      2. Ca2+PC open
      3. Ca2+ enters synaptic knob by facilitated diffusion
      4. Influx of Ca2+ = synaptic vesicles fuse with presyn membrane
      5. Release ACh into synaptic cleft
      6. ACh molecules diffuse across cleft
      7. Bind to receptor sites of Na+PC
      8. Na+PC open
      9. Na+ diffuse in rapidly along concentration gradient
      10. Influx of Na+ causes new AP in postsyn
      11. AChE hydrolyses ACh into choline and ethanoic acid
      12. Diffuse back across cleft into presyn for recycling
      13. ATP release by mitochondria used to recombine choline and ethanoic acid into ACh
      14. Na+PC close (no ACh)
    • WHAT IS ACh?
      acetylcholine
    • WHAT IS AChE?
      acetylcholinesterase
    • ANOTHER NAME FOR ETHANOIC ACID?
      acetyl