Efficient transport and exchange
All chemical reactions in your body produce waste which must be excreted. Waste may be toxic. Your body also needs to move substances into it, for chemical reactions. Many of these substances are moved by diffusion, to speed up this the surfaces are: thin + large SA.
The continual flow of blood, in capillaries, maintains the concentration gradient.
It would take too long for substances to diffuse through cells on the outside of a tissue to reach the cells on the inside. Multicellular organisms have transport systems to counter this. The larger a cell's SA, the more diffusion in a certain time. However if a cell's volume is too big, the cell cannot fill up with enough nutrients quickly enough. As cells get bigger the SA:V gets smaller, if it gets too small the cell cannot get enough raw material fast enough to stay alive.