Adrenaline, glucagon

• adrenaline and glucagon act via?

  a second messenger
• Both adrenaline and glucagon can do what?


  Activate glycogenolysis inside a cell even though they bind to receptors on the outside of the cell
• How do adrenaline and glucagon activate glycogenolysis inside a cell?

  • The receptors for adrenaline and glucagon have specific tertiary structure that make them complementary in shape to their respective hormones
  • Adrenalin and glucagon bind to their receptors and activate ADENYLATE CYCLASE
• Adenylate cyclase is what?


  an enzyme
• Adenylate cyclase is also known as what?


  Adenylyl cyclase
• How do adrenaline and glucagon activate glycogenolysis inside a cell?


  • Activated adenylate cyclase converts ATP into a chemical signal called a second messenger- this second messenger is called cyclic AMP (cAMP)
• WHat does cAMP activate?


  An enzyme called protein kinase A.
• what does protein kinase A do?


  Activates a cascade ( a chain of reactions) that breaks down glycogen into glucose (glycogenolysis)