No O_2; no final e- acceptor, no re-oxidisation, Krebs cycle + Link reaction stop, no oxidative phosphorylation or ETC
Little ATP from glycolysis, but reduced NAD must be re-oxidised + recycled; 2 mechanisms: alcoholic or lactic fermentation
Alcoholic Fermentation
Yeast cells + green plant roots when in waterlogged/anoxic conditions
Ethanol is toxic + let build up eventually kill yeast cells; process exploited in beer/wine production
Lactic Fermentation
Mammalian skeletal muscle + erythrocytes
Lactate build up in muscles during heavy exercise; cause muscle fatigue, lactate is toxic
Reversible, lactate metabolised when more O_2 available
Cori cycle: Lactate removed from muscles, liver takes recycling metabolic burden + stop dangerous pH drop
Cannot be sustained long; uses too much ATP
O_2 needed to fully oxidise lactate is called O_2 debt
Starts with glycolysis