2. once action potential reaches the end of an axon it needs to be transferred to another neurone or tissue by crossing the synaptic cleft
3. at the end of the neurone are synaptic vesicles which contain neurotransmitters
4. the electrical impulse carries signals across the synaptic gape, they bind to the receptor sites on post-synaptic cell which them becomes activated
you cannot transmit backwards because the presynaptic transmission does not have receptors so cannot transmit the action potential back across synaptic cleft