application, eg. by increasing understanding on the best time to administer drug treatements, eg. risk of a heart attack is greatest in the early morning so drugs are taken at night but not released until dusk, peak times where treatement will be most effective, however research showing things negatively impacting a person and interfering with circadian ryhyms like shift work, this leads to desynchronization of the rytyms and adverse cognitive and physiological effects - 3 times more likely to suffer from heart disease as a result of stress from adjusting to sleep wake cycles