Blood types are determined by the presence of antigens on the surface of red blood cells. The two main systems for blood typing are the ABO system and the Rh system. In the ABO system, there are A antigens or B antigens, and a person's blood type depends if they have one, two, or none of these antigens. The Rh systems determines if the blood type has the Rh antigen so Rh positive or doesn't have the antigen so Rh negative.