Cholinergic Synapse

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    • Cholinergic Synapse
      Use acetylcholine (Ach) as their neurotransmitter
      1. Action potential transmitted to presynaptic neurone end
      2. Depolarisation causes Ca2+ voltage gated channels to open + ions diffuse to synaptic bulb
      3. Ca2+ ions stimulate synaptic vesicles (~10,000 acetylcholine) to move to presynaptic membrane
      4. Vesicles fuse w/ membrane + release Ach to synaptic cleft, by exocytosis
      5. Diffuse over synaptic cleft + bind to receptor sites on Na+ channel proteins in postsynaptic membrane
      6. Before binding, postsynaptic membrane polarised
      7. Ach binds to receptor sites, Na+ channels open + Na+ diffuse to postsynaptic neurone
      8. Na+ influx depolarises postsynaptic, generator potential
      9. Ach leaves ion channels, enters acetylcholinesterase enzyme active sites, into ethanoic acid + choline; stimulation is brief
      10. Choline molecules re-enter presynaptic + re-synthesised by ATP
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