(kisses JULIET,takes out the poison)Come, bitter conduct, come, unsavoury guide.Thou desperate pilot, now at once run onThe dashing rocks thy seasick, weary bark.Here’s to my love! (drinks the poison) (5.3.125–129)
Poison is harmful and evil, but here Romeo also calls it a way, a guide, and a pilot—three things that will bring him relief. Here, poison symbolizes his escape from this world, the cruel world that took Juliet from him, the empty world with which he’s grown tired.