Pharmaceutical dosage form

• What are the three key pharmaceutical dispersions?

  Solutions, colloids, and coarse dispersions
• What is a common dosage form for conventional routes of administration?

  Tablet
• What are the qualities of an ideal dosage form?

  • Manageable size unit
  • Palatable and comfortable
  • Stable (chemically, physically, microbiologically)
  • Convenient and easy to use
  • Timely drug release with minimal side effects
• What is a tablet?

  A solid dosage form containing medicinal substances
• What routes can tablets be administered through?

  Oral, buccal, sublingual, vaginal
• What is a key consideration for oral tablets over 500mg?

  They are difficult to swallow
• Why are excipients important in tablet quality?

  They affect binding and lubrication
• What is the purpose of taste masking in oral tablets?

  To mask unpleasant flavors
• What is a capsule?

  A solid oral dosage form with a shell
• What materials can capsule shells be made from?

  Gelatin, starch, or cellulose
• What is the lag time to absorption for capsules?

  Approximately 15 minutes
• What is a key consideration for liquid dosage forms?

  They allow flexible dose adjustments
• Why are oral liquid dosage forms suitable for geriatrics and pediatrics?

  They allow for easier dosing adjustments
• What is a key disadvantage of oral liquid dosage forms?

  Stability can be an issue
• What is an injection?

  A sterile preparation for parenteral use
• What routes can injections be administered through?

  IV, SC, IM, IU, ID, IA, IP
• What is a key consideration for injectable liquids?

  They must be sterile and pyrogen-free
• What is a patch?

  A drug delivery system applied to the skin
• What is a key consideration for patches?

  Patch area is proportional to dose
• What is a drop?

  A solution administered in a drop-wise fashion
• What is a key consideration for nasal drops?

  They should be isotonic and pH 4.5-8
• What is an aerosol?

  A product packaged under pressure for topical use
• What is a key consideration for aerosols?

  Particle size can vary between 0.5-80um
• What are the three key categories of pharmaceutical dispersions?

  1. Solutions
  2. Colloids
  3. Suspensions
• What must a drug do to be absorbed and act on its target receptor?

  It must go into solution
• What does ADME stand for in pharmacology?

  • Absorption
  • Distribution
  • Metabolism
  • Elimination
• What is the significance of liberation in drug administration?

  Only drugs in solution are absorbed
• How do the properties of a drug influence dosage form design?

  They affect solubility, stability, and absorption
• What is the role of excipients in dosage forms?

  They enhance stability and drug delivery
• What is the importance of the site of action in drug design?

  It determines the drug's effectiveness
• What factors influence the selection of a dosage form?

  Patient needs, drug properties, and route
• What is the significance of processing stresses in dosage form design?

  They can affect drug stability and efficacy
• What is the role of liberation in the pharmacokinetic process?

  It allows the drug to be absorbed
• What happens to a drug after administration?

  It is liberated, absorbed, and distributed
• What is the relationship between drug solubility and absorption?

  Drugs must be in solution to be absorbed
• What is the significance of the target receptor location?

  It influences drug design and effectiveness
• What is the importance of stability in dosage forms?

  It ensures the drug remains effective over time
• What is the role of metabolism in drug action?

  It alters the drug for elimination or action
• What is the significance of elimination in pharmacokinetics?

  It removes the drug from the body
• What is the importance of distribution in drug pharmacokinetics?

  It determines how the drug reaches its target