Nucleophilic addition elimination

• Nucleophilic addition elimination

  1°amides would react with the two carboxylic derivatives (acid chlorides and acid anhydrides) to form N-substituded amides

  
• Acid chloride/acid anhydride go through nucleophilic addition elimination to form amides

  • An excess of NH3 is needed
• Acid chloride/anhydrides go through nucleophilic addition elimination to form esters

  Conditions required:

  • Reagent is alcohol
• Acid chloride/anhydride go through nucleophilic addition elimination to form carboxylic acids

  Conditions required:

  • Reagent is water