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Paper 1
infection & response
monoclonal antibodies
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Created by
Elizabeth Burr
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Cards (17)
How are monoclonal antibodies produced?
By
cloning
a single cell to produce antibodies
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What type of cells produce antibodies?
B lymphocytes
or
B cells
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What is the role of antibodies in the immune system?
To help fight disease by binding to
antigens
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What are antigens?
Foreign materials that
antibodies
bind to
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How do antibodies recognize bacteria?
By binding to specific
antigens
on bacteria
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What is the significance of hybridoma cells in monoclonal antibody production?
They produce
antibodies
and divide rapidly
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How are hybridoma cells created?
By fusing
B cells
with fast-dividing
tumor cells
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What is the purpose of injecting an animal with an antigen?
To stimulate an
immune response
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What happens to the B lymphocytes after the animal is injected with the antigen?
They produce specific
antibodies
against the antigen
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Why can monoclonal antibodies be designed to bind to specific targets?
They are derived from specific
B
lymphocytes
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How can monoclonal antibodies be used in cancer treatment?
By attaching drugs or
radioactive
material to them
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What is the advantage of monoclonal antibodies in targeting cancer cells?
They bind specifically to cancer cell
antigens
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What are the steps involved in producing monoclonal antibodies?
Inject an animal with the
antigen
.
The animal's immune system produces
B lymphocytes
.
Isolate the specific B lymphocytes.
Fuse B lymphocytes with fast-dividing tumor cells to create
hybridomas
.
Allow hybridomas to divide and produce antibodies.
Collect and purify the monoclonal antibodies.
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What is the shape of antibodies often represented as?
Y shapes
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What can be attached to monoclonal antibodies for therapeutic purposes?
Drugs,
fluorescent proteins
, or
radioactive material
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How do monoclonal antibodies locate cancer cells in treatment?
By binding to specific
antigens
on cancer cells
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What is the main benefit of using monoclonal antibodies in medicine?
They target
specific
cells or proteins
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