Nicotine replacement therapy provides a nicotine dose using skin patches, gum, tablets and nasal spray instead of tobacco. The dose is more controlled and cleaner. Gum, inhalers and sprays have immediate effects to reduce cravings, patches have long term benefits. Combining two methods can be the most effective. The nicotine molecules attach to receptors in the VTA and this stimulates the release of dopamine in the NA. withdrawal symptoms can be managed as the doses can be reduced over time, avoiding chance of relapse.