Throughout the play, blood is used as a symbol for guilt.
Before killing Duncan, Macbeth is aware that there will be a lot of blood and uses the euphemism for murder in "bloody business". He's worried the blood will betray him.
Literal blood is prevalent: the bleeding captain who speaks about Macbeth to Macbeth's bleeding head at the end.
According to Macbeth "Neptune's ocean" could not wash away the blood (guilt) from his hands. Lady Macbeth sleep walks, unable to clean the blood from hers.
"I am in blood, stepped in so far, that should I wade no more, returning as I were as tedious as go o'er": Macbeth feels he has done too much and is too guilty to turn back and change his ways.
"What bloody man is that?" (King 1:2)
"Make thick my blood; / Stop up the access and passage to remorse" (Lady Macbeth 1:5)
"And on thy blade, and dudgeon, gouts of blood" (Macbeth 2:1)
"Will all great Neptune's ocean wash this blood clean from my hand?" (Macbeth 2:2)
"My hands are of your colour, but I shame to wear a heart so white" (Lady Macbeth 2:2)
"The spring, the head, the fountain of your blood is stopped, the very source of it stopped" (Macbeth 2:3)
"Their [guards] hands and faces were all badged with blood" (Lennox 2:3)
"It will have blood they say: blood will have blood" (Macbeth 3:4)
"I am in blood stepped in so far, that should I wade no more, returning were as tedious as go o'er" (Macbeth 3:4)
"Twenty trenched gashes on his [Banquo's] head" (Murderer 3:4)
"Never shake thy glory locks at me" (Macbeth 3:4)
"Avaunt! And quit my sight! Let the earth hide thee, thy [Banquo's] bones are marrowless, thy blood is cold" (Macbeth 3:4)
"Cool it with a baboon's blood" (Weird Sisters 4:1)
"Bleed, bleed, poor country!" (Macduff 4:3)
"The blood bolter'd Banquo smiles upon me" (Macbeth 4:1)
"[Scotland is a] Nation miserable with an untitled tyrant bloody scepter'd" (Macduff 4:3)
"Out, damned spot: out I say" (Lady Macbeth 5:1)
"Yet who would have thought the old man to have had so much blood in him?" (Lady Macbeth 5:1)
"Here's the smell of blood still. All the perfumes of Arabia will not sweeten this little hand" (Lady Macbeth 5:1)
"Revenges burn in them; for their dear causes / Would to the bleeding and the grim alarm, excite the mortified man" (Menteith 5:2)