Rheumatoid arthritis overview

• What problems with adaptive immunity can lead to autoimmune diseases?

  Problems with adaptive immunity can lead to autoimmune diseases.
• How do problems with innate immunity relate to autoimmune diseases?

  Problems with innate immunity can contribute to autoimmune inflammation.
• What is the definition of rheumatoid arthritis (RA)?

  RA is based on the presence of synovitis in at least one joint, absence of alternative diagnosis, and achievement of at least 6/10 points on the classification criteria.
• How much more common is rheumatoid arthritis in women compared to men?

  Rheumatoid arthritis is 3 times more common in women.
• What is the relationship between age and the prevalence of rheumatoid arthritis?

  The prevalence of rheumatoid arthritis increases with age.
• What genetic predisposition is associated with the development of rheumatoid arthritis?

  Genetic predisposition is linked to the development of RA, particularly involving HLA-DRB1 genes.
• What environmental factors can trigger rheumatoid arthritis?

  Environmental triggers include protein stimulation and post-translational modifications.
• What is a common symptom of rheumatoid arthritis?

  Common symptoms include painful joints and swelling in small joints.
• How does the onset of rheumatoid arthritis typically develop?

  The onset of rheumatoid arthritis usually develops over a few weeks to a few months.
• What are some complications associated with rheumatoid arthritis?

  Complications can include nodules, ulcers, and vascular disease.
• What are key indicators of poor outcomes in rheumatoid arthritis?

  Key indicators include genetics, high ESR or CRP, many active joints, and adverse socio-economic circumstances.
• What are the prognostic factors for rheumatoid arthritis outcomes?

  • Genetics: HLA-DRB1 genotype present in more severe forms
  • Laboratory results: high ESR or CRP, positive RF and ACPA
  • Clinical assessment: many active joints, poorer functional scores
  • Other factors: earlier radiological lesions, adverse socio-economic circumstances
• What is the expected outcome if rheumatoid arthritis is untreated for 2 years?

  • Radiological evidence of joint damage
  • Increased risk of disability
  • Poor quality of life
• What are the potential consequences of aggressive rheumatoid arthritis if left untreated?

  • Rapid functional decline
  • Increased comorbidity and mortality
  • Significant impact on quality of life
• What imaging techniques can be used to assess rheumatoid arthritis?

  • Power Doppler ultrasound
  • MRI for early detection
  • Radiography for joint damage assessment