Multiple dose regimes 2

• What does the accumulation model relate to in pharmacokinetics?

  It relates the dosing interval to the accumulation of drug concentration over time.
• What happens to drug accumulation when the dosing interval is long relative to the elimination rate?

  Accumulation is low.
• What occurs when the dosing interval is short relative to the elimination rate?

  Accumulation is high.
• What is the formula for the accumulation ratio?

  R = Cmax/Cmin = Cmax/Cumin.
• What is the equation for the accumulation ratio in terms of time?

  R = e^kt.
• How is the elimination rate constant (k) calculated?

  k = (Cmax - Cmin) / (t).
• What effect does more frequent administration have on drug accumulation?

  It increases accumulation for a given half-life.
• What are the steps involved in obtaining a dose regimen?

  • Choose target concentration.
  • Use desired Co and Cl to estimate accumulation rate.
  • Establish appropriate administration interval (τ).
• What is required to reproduce Cmax with the bivocous model?

  Required Cmax and k.
• What is the formula for calculating the urgent dose needed period?

  Cmax = O/(1-(e^-kt)).
• What is the process for ensuring the desired regimen leads to effective dosing?

  • Predict Cmax.
  • Predict Cmin.
  • Ensure doses are maintained within target levels.
• How is the mean area under the curve (AUC) calculated?

  Mean areas II = C1t + C2t.
• What does the leading maintenance dose refer to in intravenous administration?

  It refers to a repeated intravenous seminal dose taken every T.
• What is the formula for calculating the initial concentration (Co) after an IV bolus and fast absorption?

  Co = D/(V (1-e^-kt)).
• What does Dm represent in the context of extravascular dosing?

  Dm represents the dose administered extravascularly.
• What is the formula for calculating Dm in extravascular dosing?

  Dm = (1-e^-kτ)(1-e^-kτ).