5.4 - B cells + humoral immunity

• What does humoral immunity involve ?

  Antibodies
• What cells does humoral immunity involve ?

  B cells
• Where do B cells develop ?

  Bone marrow
• What’s clonal selection ?

  The process of matching the antigens on an APC with antigen receptors on B cells that are complementary
• What’s a monoclonal antibody ?

  An antibody made by clonal expansion of a B cell that‘s specific to one type of antigen
• What 2 cells can B cell clones differentiate into ?

  Plasma cells and memory B cells
• What’s an antibody called when it’s still attached to the cell surface ?

  B cell glycoprotein receptor
• A B cell glycoprotein receptor is only called an antibody once it’s free of the cell membrane. True or False ?

  True
• What do plasma cells do ?

  Secrete antibodies into blood plasma
• What’s the production of antibodies and memory cells called ?

  Primary immune response
• Are plasma cells short or long lived ?

  Short lived
• What response are memory cells responsible for ?

  Secondary immune response
• Are memory cells long or short lived ?

  Long lived
• What kind of immunity do memory cells provide ?

  Long-term immunity
• What do memory cells result in, in terms of antibody production ?

  An increased number of antibodies secreted at a faster rate
• 1st step of B cell response ?

  B cell receptor binds to complementary antigen and are taken in by the B cell
• 2nd step of B cell response ?

  Processes antigen and presents them on its surface
• 3rd step of B cell response ?

  An activated helper T cell binds to the specific competent B cell and activates the B cell
• 4th step of B cell response ?

  B cell is stimulated to divide by mitosis (clonal expansion), gives a cloned plasma cell
• 5th step of B cell response ?

  Cloned plasma cells secrete specific Ab for the antigen and they attach and destroy them
• What can the cloned plasma cells develop into ?

  Memory cells