Co-morbidity is when two or more conditions occur together. If conditions occur together a lot of the time it might call into question whether they are actually a single condition. Buckley et al. concluded that around half of patients with a diagnosis of schizophrenia also have a diagnosis of depression (50%) or substance abuse (47%). In terms of classification, if very severe depression looks like schizophrenia and vice versa, it may be that they are a single condition. This confusing picture is a limitation