Typical Antipsychotics

• Also known as First generation antipsychotics
• Administration

  Orally through tablets or syrup

  Can be administered via injection if high risk of non-compliance
• Chlorpromazine

  Acts as an antagonist in the dopamine systems - reducing the action of the neurotransmitter

  Dopamine antagonists block dopamine receptors in the synapses, reducing dopamine action

  Initially dopamine levels are higher, but production is then reduced
• Chlorpromazine

  According to the dopamine hypothesis, the dopamine-Antagonist effect normalises neurotransmission in key areas of the brain reducing symptoms like hallucinations

  Also works as an effective sedative, calming people with schizophrenia
• Side effect - Tardive Dyskinesia

  Uncontrollable movements, especially around the mouth

  • An EPSE - symptoms in the brains cerebral cortex
• Side effects

  Drowsiness

  Constipation

  Low blood pressure

  Abnormal sexual functioning

  Rarely coma and death