19,000 Finnish children whose biological mothers had been diagnosed with SZ
This genetic risk group compared to control group of adoptees w/o family history of SZ.
Adoptive parents assessed and children who had parents with negative environment were associated with development of SZ but only in high genetic risk group
Real world application
Combination of drug treatment and psychological therapies enhances the effectiveness.
Limitation - original model
Original model is too simplistic.
Doesn't acknowledge that biological + psychological factors can be diathesis and stress.