1.2 Action Potential in Cardiac Muscle

Cards (23)

  • What is the average action potential recorded in a ventricular muscle fiber?
    About 105 millivolts
  • What is the intracellular potential in ventricular muscle fibers between beats?
    About โˆ’85 millivolts
  • What is the intracellular potential during each beat in ventricular muscle fibers?
    About +20 millivolts
  • How long does the membrane remain depolarized during the action potential?
    About 0.2 seconds
  • How much longer does ventricular contraction last in cardiac muscle compared to skeletal muscle?
    About 15 times longer
  • What are the major differences between cardiac and skeletal muscle action potentials?
    • Cardiac action potential has a plateau.
    • Cardiac muscle has L-type calcium channels.
    • Skeletal muscle has fast sodium channels only.
    • Cardiac muscle has prolonged depolarization.
  • What causes the action potential in skeletal muscle?
    Sudden opening of fast sodium channels
  • How long do fast sodium channels remain open in skeletal muscle?
    Only a few thousandths of a second
  • What happens at the end of fast sodium channel closure in skeletal muscle?
    Repolarization occurs
  • What types of channels cause the action potential in cardiac muscle?
    Fast sodium channels and L-type calcium channels
  • How do L-type calcium channels differ from fast sodium channels?
    They are slower to open and stay open longer
  • What ions flow through L-type calcium channels during cardiac action potential?
    Calcium and sodium ions
  • What effect does calcium influx have during the plateau phase of cardiac action potential?
    It activates the muscle contractile process
  • What happens to potassium ion permeability immediately after the action potential begins in cardiac muscle?
    It decreases about fivefold
  • What is the consequence of decreased potassium permeability during the action potential plateau?
    It prevents early return to resting potential
  • What happens when slow calcium-sodium channels close?
    Potassium permeability increases rapidly
  • What is the average resting membrane potential in cardiac muscle?
    About โˆ’90 millivolts
  • What is the velocity of conduction of the action potential in cardiac muscle fibers?
    About 0.3 to 0.5 m/sec
  • How does the conduction velocity in Purkinje fibers compare to cardiac muscle fibers?
    It can be as great as 4 m/sec
  • What is the refractory period of the ventricle in cardiac muscle?
    About 0.25 to 0.30 seconds
  • How does the refractory period of atrial muscle compare to that of ventricular muscle?
    It is much shorter than ventricular muscle
  • What is the duration of the relative refractory period in cardiac muscle?
    About 0.05 seconds
  • What can cause a premature contraction in cardiac muscle?
    A very strong excitatory signal