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๐ซC9. Cardiac Muscle; The Heart as a Pump
1. Physiology of Cardiac Muscle
1.2 Action Potential in Cardiac Muscle
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Cards (23)
What is the average action potential recorded in a ventricular muscle fiber?
About
105
millivolts
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What is the intracellular potential in ventricular muscle fibers between beats?
About
โ85
millivolts
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What is the intracellular potential during each beat in ventricular muscle fibers?
About +20
millivolts
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How long does the membrane remain depolarized during the action potential?
About
0.2
seconds
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How much longer does ventricular contraction last in cardiac muscle compared to skeletal muscle?
About
15 times
longer
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What are the major differences between cardiac and skeletal muscle action potentials?
Cardiac action potential has a
plateau
.
Cardiac muscle has
L-type calcium channels
.
Skeletal muscle has
fast sodium channels
only.
Cardiac muscle has prolonged
depolarization
.
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What causes the action potential in skeletal muscle?
Sudden opening of
fast sodium channels
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How long do fast sodium channels remain open in skeletal muscle?
Only a few
thousandths
of a second
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What happens at the end of fast sodium channel closure in skeletal muscle?
Repolarization
occurs
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What types of channels cause the action potential in cardiac muscle?
Fast sodium channels
and
L-type calcium channels
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How do L-type calcium channels differ from fast sodium channels?
They are
slower
to open and stay open
longer
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What ions flow through L-type calcium channels during cardiac action potential?
Calcium and
sodium
ions
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What effect does calcium influx have during the plateau phase of cardiac action potential?
It activates the
muscle contractile process
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What happens to potassium ion permeability immediately after the action potential begins in cardiac muscle?
It decreases about
fivefold
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What is the consequence of decreased potassium permeability during the action potential plateau?
It prevents early return to resting potential
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What happens when slow calcium-sodium channels close?
Potassium permeability
increases rapidly
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What is the average resting membrane potential in cardiac muscle?
About โ90
millivolts
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What is the velocity of conduction of the action potential in cardiac muscle fibers?
About
0.3 to 0.5 m/sec
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How does the conduction velocity in Purkinje fibers compare to cardiac muscle fibers?
It can be as great as
4 m/sec
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What is the refractory period of the ventricle in cardiac muscle?
About
0.25
to
0.30
seconds
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How does the refractory period of atrial muscle compare to that of ventricular muscle?
It is much shorter than ventricular muscle
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What is the duration of the relative refractory period in cardiac muscle?
About
0.05 seconds
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What can cause a premature contraction in cardiac muscle?
A very strong
excitatory signal
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